Nidus Prime

The Plague Knight | Nidus Prime

by last updated 5 months ago


Mutation is endless. The ravening plague-bearer returns in a long-unseen form, seething with a primal strain of the Infestation.




60 / 60


Damage Reduction
Nidus Prime builds
Builds by UltimoFive

The Plague Knight | Nidus Prime

Hello everyone,

My name is UltimoFive and today we are going over [Nidus Prime], The Plague Knight.

Frame Information

  • [Nidus Prime] is the Prime version of [Nidus] and was released alongside [Strun Prime] and [Magnus Prime]. In order to obtain [Nidus Prime] one must open a variety of relics that contain his Blueprint, Chassis, Systems, and Neuroptics in order to make him at the foundry.

  • Nidus Prime requires a Mastery Rank of 0.

  • [Nidus Prime] comes with a "Dash", “V” and "D" Polarity Slot, plus a "V" Aura Slot. Because of this, the builds on him will require 2 - 3 forma.

  • [Nidus Prime] is an extremely versatile frame in which his abilities can be used for Devastation, Buffing, or Protection.

Comparison to the Original Nidus

Nidus Prime has been buffed compared to the Original Nidus. These buffs would be:

  • Higher Health Pool at 175/525 Vs. 150/450

  • Higher Armor at 350/525 Vs. 300/450

  • Higher Energy Pool at 125/188 Vs. 100/150

Advantages Vs. Disadvantages


  • Very High Health Pool at 175/525

  • Very High Armor at 350/525


  • Below Average Energy Pool at 125/188

  • No Shields. However, this can be advantageous with the synergy of Hunter Adrenaline

Ability & Augmentation Overview

  • Passive - [Nidus Prime]'s Passive is an infestation dwelling within himself, which mutates when he uses his Abilities against those that stand before him. This infestation is seen as Mutation Stacks which go up upon a player hitting enemies with Virulence or Ravenous and after 5 enemies are hit, a Mutation Stack is obtained. Along with this, Larva has a Random Chance to generate a stack as well. Another Passive is that when he takes Fatal Damage and he has at least 15 stacks, they will be consumed and grant [Nidus Prime] with 5 Seconds of Invulnerability and restores 50% of his health. With his Augmentation, [Abundant Mutation], the max number of stacks for [Nidus Prime]'s Passive increases from 100 to 300. This Passive is pretty good for the reason that there isn't too much of a consequence of dying, other than the consumption of 15 of his stacks. Along with this, his Augmentation does sadly add a cooldown of this Undying State but isn't that much of an issue.

  • Virulence - [Nidus Prime]'s First Ability ruptures the ground to unleash a fungal infestation in a linear path. Enemies struck by the growth are staggered, amplify [Nidus Prime]'s Mutation Stacks, and refund energy per enemy hit. With his Augmentation, [Teeming Virulence], [Nidus Prime]'s Primary Weapons is granted a Critical Chance Buff upon hitting 4 enemies with a single use of Virulence. This Ability is amazing due to just how easily it can deal with all enemies without any worry. Its augmentation is even pretty good for the reason of just granting a Critical Chance Buff for your Primary Weapon, which may I say can be a lot if built well. In my case I was able to achieve 303% Critical Chance and just decimate everything, either with the ability or with my Primary.

  • Larva - [Nidus Prime]'s Second Ability ejects an Infested Larva towards a targeted location that upon impact or reactivation matures and sprouts tendrils that grab all enemies within a certain Distance and ragdolls them into the Infested Mass. This renders them helpless while meshing them together within the Infested Larva. With his Augmentation, [Larva Burst], it allows the player to recast the ability to detonate it and deals Toxin damage proportional to the enemies trapped within. This ability pairs extremely well with Virulence and is a main Combo with the 2 abilities. Simply use your second ability, and then spam your first ability until all within the Mass are dead. That is pretty much all there is, it is an extremely good ability that helps power your first ability up faster or to just Combo. However, it's augmentation I never could find an application for, maybe it could be decent against Corpus Enemies with some Range Focused Toxin Build.

    Like this one, which honestly is great against the Corpus, even into the Steel Path if one gathers enough enemies with Larva.

  • Parasitic Link - [Nidus Prime]'s Third Ability expends a Mutation Stack to perform symbiosis onto an Allied Warframe that grants himself and his target increase Ability Strength and Damage. However, when he parasitically links onto a Targeted Enemy, [Nidus Prime] will transfer up to 90% damage he receives to the target instead, while the victim is completely disabled. The link persists as long as his target remains in range of each other as well. This Ability is a coin flip really, it doesn't have any practicality for survival unless one is in Arbitration, the Steel Path, or just high leveled enemies in general, which is where I mainly only use the ability. However, if one feels a bit riskier, then attaching to an ally to just overwhelm enemies in these situations can prove to be beneficial as well, just as long as the player is using the Virulent Scourge or Plague Shaman Builds.

  • Ravenous - [Nidus Prime]'s Fourth Ability converts three Mutation Stacks into a massive infestation that spreads outward from [Nidus Prime] and across the surrounding landscape. Upon this landscape are infested cysts that hatch Maggots that seek out nearby enemies to feast upon. Along with this any ally within the landscape is granted increased Health [Regen] With his Augmentation, [Insatiable], Ravenous grants him a chance to generate an additional Mutation Stack when gaining one while standing upon the infested grounds. This ability is good in a multitude of ways, meanwhile his Augmentation, in my opinion, not so much. This ability can be used to keep [Nidus Prime] and his allies alive, can be used to keep defensive objectives alive, or can be used as a defensive stand against a swarm of enemies, such as those in a Survival Mission. This is at least the applications I used his fourth ability for, but this ability can do a lot more. For instance, I focused on primarily the Health [Regen] and CC from the Maggots that spawned.


Deadly Pest: 3 Forma

The Deadly Pest Build for [Nidus Prime] utilizes an Extremely Large Increase to Strength, with a Large Increase to Range and Decreases to Duration and Efficiency. The Build's Flex Slot is [Augur Reach] or [Abundant Mutation] and focuses on [Nidus Prime]’s First and Second Ability Spam mixed with his Third and Fourth Ability for Survival, if need be. The Build works perfect into extremely late game due to the increased capped stacks one can obtain through the use of [Abundant Mutation] in order to increase Virulence's Power even further.

[Virulent Scourge]: 3 Forma

The [Virulent Scourge] Build for [Nidus Prime] utilizes a Very Large Increase to Strength, with Medium Increases to Duration and Range and a Large Decrease to Efficiency. The Build's Flex Slot is [Augur Secrets] and focuses on Buffing the Players Primary Weapon by increasing Critical Chance by 303%. Even though that is the Build's Prime Focus, it still can work efficiently with [Nidus Prime]'s 1, 2 Combo in having two ways to just decimate enemies.

Plague Shaman: 3 Forma

The Plague Shaman Build for [Nidus Prime] utilizes an Extremely Large Increase to Strength, with Medium Increases to Duration and Range and a Large Decrease to Efficiency. The Build's Flex Slot is [Augur Message] and focuses on Defense, even though it is similar to the previous Build. Essentially use Ravenous to help [Regen] Objectives and keep them safe from enemies, but again. It can still use [Nidus Prime]'s 1, 2 Combo in order to successfully defend yourself and objectives.

Recommended Alternative Modifications

First off, the Aura slot can be whatever one wants it to be. As long as it benefits one and what they are during currently than realistically anything can work there. For instance, [Growing Power] is a Great Aura mod to increase Ability Strength, but [Steel Charge] can be a better choice. You could even use an Aura Forma on him so any mod could go there and not just Madurai "V" mods.

  • Intensify - In place of Umbral Intensify if one doesn't have it.

  • Continuity - In place of Primed Continuity if one doesn't have it.

  • Rage - In place of Hunter Adrenaline if one doesn't have it.

  • Chroma's Elemental Ward - In place of Parasitic Link or Ravenous if one wants optional buffs that can assist them into battle.

  • Garuda's Blood Alter - In place of Parasitic Link or Ravenous if one wants a way to Regen Health for themselves or the Team.

  • Rhino's Roar - In place of Parasitic Link or Ravenous in the Virulent Scourge Build if one wants a way to further increase Primary Weapon Damage.

Arcane Synergy

  • Arcane Energize - Upon Energy Pickup, 60% chance to replenish Energy to nearby allies.

  • Arcane Grace - Upon Health being Damaged, 9% chance for 6% Health Regen for 9 seconds.

  • Arcane Victory - Upon Headshot Kill, 75% chance for 3% Health Regen for 9 seconds.

  • Arcane Guardian - Upon being Damaged, 15% chance for 900 Armor for 20 seconds.

  • Arcane Nullifier - Which provides a 102% chance to resist a Magnetic Status Effect entirely.


If you guys enjoyed and liked the guide, make sure to give it a ⭐ to help out! To help out even more, why not check out my channel where I not only make guides and builds, but also stream games, make Playthroughs, and more!

Link for my Channel 🠖

See you guys on the next guide!