Immortal Nova -
Max duration for 90% damage reduction on null star. [Molecular Fission] to keep your null star at 18 total at all times.
Molecular prime to keep enemies at a crawl. Really solid for keeping her alive while also supporting your team. The damage increase it applies is also really nice. I love this ability and it helps amplify all aspects of [Nova].
Subsume pillage on to give her massive overshields. Combine with [Adaptation] and null star to make her damage reduction incredibly high. Enemies that do hit you, are also crawling at 74% reduced speed (75% is the cap, and will be hit if you proc a status before casting, due to growing power).
Wormholes are semi-optional but good for easy quick positioning.
I recommend energize for ease of use and pillage spam, but the other arcane is personal preference. I like avenger because the damage reduction you'll have will let you proc it without much worry, and 45% flat increase on crit is always nice (have you seen the crit multiplier on [Nukor]?)
This [Nova] focuses on survivability, while amplifying her own damage with armor strip (thanks pillage) and through priming with molecular prime.
Overall, I love this build for everything except defense, that's when i want speed nova (build here: https://overframe.gg/build/126689/)
Check out a stream for more builds, of if you have questions! twitch.tv/severedsanity