[Nova] can use Wormhole to speedrun some mission types faster than any other frame in the game. We subsume an additional movement speed ability allow her to move more quickly in small hallways with sharp turns.
Infested Mobility is chosen because it's the most versatile movement ability. Molt is stronger but requires you to spam it far more often. Fire Walker is weaker but lasts significantly longer and gives status immunity while you're on the ground running.
Null Star is replaced because even though Molecular Prime and Antimatter drop are useless in most speedrunning content, sometimes these builds require you to attack a boss or capture target and they can be useful in those situations.
[Rolling Guard] is a flex mod that provides the bare minimum of survivability options through all content. Replace it with any mod as you see fit.
Arcane Agility and Consequence significantly increase your movement through parkour velocity but may be difficult to proc in some content. Either can be replaced with Arcane Nullifier if you're speedrunning missions that have a lot of nullification door traps.