[Grendel]'s kit already works well without significant stat investment due to the way it scales with enemy level. This allows us to spend a lot of mods on more survivability to make him a nearly unkillable tank.
Base abilities are run for this General Use build because each ability serves a purpose. Regurgitate allows us to control the enemies in our gut and Pulverize is overly tanky because enemy AI has a tough time trying to aim at it. Fire Blast is a decent all-around option if you want to replace either ability.
[Brief Respite] allows [Grendel] to get a significant portion of his shields back, making his shield gates last longer. You can abuse this even further by running a Decaying Dragon Key.
[Primed Sure Footed] is one of the strongest QoL mods in the game and when you're planning on taking a lot of hits you should probably run it.
[Natural Talent] helps your abilities to feel more fluid. It synergizes with several aspects of the kit including [Brief Respite] and ability spam.
Arcane [Guardian] is a flex arcane that increases your survivability in general content. It can be replaced with any other arcane to suit your playstyle.