With Void Strike, every grenade deals 23.86 million damage on average, including heat procs. For reference, a standard [Glaive Prime] heavy attack build(the meta anti acolyte weapon) with Voidstrike would deal just 620,800 damage worth of slash ticks. A single grenade deals 38.4x the burst damage, with no setup apart from heat stacking.
No multishot because that's bugged on grenades, and also because of it being wasted on the acolyte status cap. The synth holster reload mods allow for fast and ammo efficient partial reload, to retrigger full grenade throws.
Can be combined with an armour stripping melee nicely.