This [Lesion] build is nothing short of insane. It will [Shred] lvl190 Exo Gokstad Officers (1000 Ferrite Armor, 1000 Cloned Flesh) in about 5 seconds with no buffs, primer, downtime or buildup whatsoever. In other words it will shred anything you put in front of it that isn't immune to status effects almost as fast as a Meta Bloodrush/[Weeping Wounds] build, but works with any focus school, on any kind of mission with no downtime on your damage.
The weapon can apply Toxin without being modded for it which mean you only need a cold mod to make viral, but even better is it can still proc cold for another stack of [Condition Overload]. I was running [Carnis Mandible] on this, but it turns out that skewing slash further with [Buzz Kill] is actually more effect. [Boreal's Contempt] is multiplicative making it amazing for Slash builds.
Due to the build up of meta builds this offers much higher TTK and KPS unless you are running Zenurik focus school or just don't prefer using your melee for everything. Meta builds will kill faster once you're at full combo stacks, but not nearly a big enough difference in TTK to make up for the hassle of trying to keep your combo stack in more spread-out maps or if you like using your guns.