Quick Note

This was just a dumb fun challenge for myself, to see if it was possible to create a levelcap viable loadout with all 4 dragon keys taken into account. Every part of the loadout has been carefully chosen for a specific purpose, and everything needs to be used in tandem to accomplish the 4 Key challenge. That being said, this loadout (extra links below) is very accessible and pretty fun in almost any content, and it's more than just 4+1 or Breach [Talons] or Gloomruda (not that I have anything against those, but I like to think this is pretty unique).

Other prerequisites
Use with Madurai, a [Felarx], a viral heat [Epitaph], a [Xoris], 2 pistol augur mods, and a [Panzer Vulpaphyla] with [Martyr Symbiosis].

Damage

Extinguished Dragon Keys make you deal ¼th the damage you should be doing, so they are by far the most problematic keys

The main room clearing will come from her signature 1+4 combo, but with some add-ons to counteract the extinguished dragon key and make play more comfy.

+40% str from Madurai gets her to exactly 134% str, the 100% slash status chance breakpoint, and casting speed is helpful too. An r5 [Blind Rage] allows for 46% comfier casting. Both [Vigorous Swap]'s and Arcane Arachne's damage buffs directly affect her dread orb, allowing her to deal 4.1x the damage she normally would.

Felarx - https://overframe.gg/build/348724/

The [Felarx] would be used mainly to take out high level overguard, as well as demolysts, since both scale faster than [Garuda]'s nuke. This gun was chosen because alongside having its 21x buff, [Galvanized Savvy] stacks multiplicatively with base damage on it, and it passively reloads it's magazine whenever you swap to your primer. This is also another reason why [Vigorous Swap] and Arcane Arachne are important, since this gun will have a hard time keeping up Primary Merciless stacks, and galvanized savvy is treated as a separate multiplier.

Xoris - https://overframe.gg/build/355511/

The [Xoris] will be used for the sole purpose of taking out Acolytes, since Acolytes have a status effect cap that favours single big hits. At 2x multi, with viral and [Garuda]'s passive, a headshot explosion would deal 530 mil slash damage over 13 seconds to an Acolyte.

With its infinite combo duration, she could build up a 12x combo in 12 hits, then forget about it until an Acolyte comes along. This ensures both orange/red crits and a 12x multiplier for a guaranteed one shot. [Vigorous Swap] and Arcane Arachne apply multiplicatively to base damage on explosion, further increasing its potential. And finally, while [Condition Overload] is currently bugged with [Glaive] explosions, Void Strike can more than make up for it with its +1000% damage buff. When an acolyte does come, use Void Strike, press 4 to force slash, throw and blow the [Glaive], and easily kill it in one shot.

*Survivability

Decaying Dragon Keys are essential to shieldgating, and Bleeding Dragon Keys are arguably more buffs than nerfs on [Garuda] too, especially at levelcap where a one shot is a oneshot anyway. That aside, I still wanna point out everything that will keep her alive during the run.

Since her nuke is infinitely scaling, with a range larger than most rooms, and relatively easy to spam, enemies nearby shouldn't really be alive to hurt her in the first place.

If enemies do stay alive a little too long, it's okay because both her 1 & 4 give her I-frames, and her 3 can easily status cleanse.

Finally, with Radial Blind working on aggro mechanics and not LOS (much more consistent), enemies should be perpetually blinded. And for CC immune enemies, 200% casting speed means you have a one-handed, 0.4s shield gate that you can spam as much as you need, with [Martyr Symbiosis] to save you if you mess up.

Movement

Hobbled Dragon Keys can be pretty annoying, but with [Garuda], the easiest and best way to move has always been leaping to targets with her 1, so they're pretty much non issues with her. That being said, this is another reason why I chose a [Xoris] over other melees, so she wouldn't have to worry about acolytes getting out of range, or her being unable to escape.

Might as well mention simple movement tech, since it isn't affected at all by the Key - bjump > jump > roll, in quick succession and while always holding aimglide.