You probably think that low efficiency is a big problem here... it's not. Energy Refund per hit let you spam Virulence and Larva and gaining stacks of Mutation very quickly. Very high strength and average duration and range let you use every his skills efficiently, high survivability make him one of the best tank in game. And the best thing here is that he is getting better with every Stack he gain.
I simply LOVE HIM for his amazing synergy between his skills. One of the best frame in game. [Nidus] is one of my favorite frames so I tested him in a lot situations... this build is ultimate solution for any troubles. And it's viable for any configurations. Which I'll give you of course.
This is my configuration A. Build for endless missions.
Suggested arcanes are Grace & [Guardian].