I created this build for Steel Path endless runs (Survival, etc), but it also works good on any "mobile" missions too.
Resonator calm down all enemies in area and force them to follow it. This means mobs are totally ignore you and you can kill them without any resistance. Thanks to Resonator you can go to any mission with any level without fear of death. For safety i use [Rolling Guard], so in unforeseen circumstances, I have 3 seconds of literal immortality to stabilize the situation.
Resonator also works great with Strangledome, because it's like bait - mobs follow the roller and get caught in your chains
Don't be afraid for Venari. She still will be active and will respawn after death when default timer ends. If you replace 3-th ability, you just lose the ability to resurrect she by pressing the button yourself, and you also cannot select Venari mode - it will always be in attack mode.
Anyway, if you very attached to your cat, you can replace Ensnare instead of Venari ability.
Here is video sample, how Resonator basically works:
And here is my stat-sticks:
Why [Kama] and [Kestrel]? Because of very high riven disposition and low prices for riven mods for these weapons. Mod for [Kestrel] i bought for 80 plat, lol.
But you can choose any weapon you like or even dislike, just be sure you got nice riven mod for it.