With innate toxin, very high base damage, and forced slash procs on [Stinging Thorn] neutral combo, the [Karyst Prime] is a nearly perfect weapon for super high level missions.

With the base toxin, you only need 1 cold mod to create viral, and here we have gone with an unranked [Vicious Frost] to make slash procs more common. On the hits with a forced slash proc, it is not uncommon to get 2 slash and 1 viral per hit.

Berserker and [Primed Fury] stack multiplicativly, and this alleviates the only real issue for [Karyst Prime], its slow attack speed.

Run with Naramon Power spike for max effectiveness.