The God of the Infection laughs at damage.
When calculated using [Nidus]' 3 on an enemy, along with Arcane [Guardian] he ends up around 132k EHP, much higher than even [Inaros] (at 71k).
This [Nidus] build focuses a lot around endgame survivability and damage.
Stacking early revolves around taking damage for energy using [Hunter Adrenaline] then using the combination of larva and virulence.
If you find you are ok with less energy due to [Hunter Adrenaline], using [Insatiable] is a good option for early stacks if you will be in one area for a bit.