-=-=UPDATED 2.5.2025=-=-
Primed Smite Orokin was removed from this build as I've been doing Hex Standing grinds lately. As the tag says though, this build always remains with the same foundation of versatile and interchangeable segments that allow you to focus damage directly towards a faction if you wish to do so. Although Primed Smite Orokin was replaced for Gladiator Might, I will still at times put it back when doing long Orokin Survivals or Relic Survivals. Same for it it was Grineer or Corpus, although Corpus are usually weak enough that you never REALISTICALLY ever need a faction mod for them.

-=-=UPDATED 1.27.2025=-=-
With 1999's Scaldra and Techrot Factions - you can replace Primed Smite Orokin or whichever faction mod you have placed into this build, if any, with Gladiator Might.
If you are more inclined to heavy attacks, you may also replace it with Killing Blow and you could even swap Organ Shatter for Amalgam Organ Shatter if you would like.
If you are more inclined to Status Damage, it may take a re-forma if you dont have a D polarity in it's slot already, but you my also replace it with Galvanized Elementalist
If you are more inclined to Speed and Combo Count, you may also replace it with Quickening

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-=-=UPDATED 8.3.2024=-=-
Added Condition Overload directly in place of Primed Pressure Point for it to act more Universal than before and for easier viewing of this build at it's Top Level.
Doing this change on this post also allows other players who PRIMARILY use Melee (meaning barely using their Secondary and Primary) to see this and not worry too much about needing to take a Primer with them or plan around replacing Primed Pressure Point for a build that focuses on using an external Primer. Heat, Viral, and Corrosive (3 Status Effects, 80 x 3 = 240) not even counting ALL of the Status Effects, there is already a 240% increase in damage- a very noticeable difference when compared to Primed Pressure Point's statis 165% Melee Damage Increase.
The Status Effects present on the weapon of course do well in their own category outside of Condition Overload synergy, and Primed Pressure Point's raw damage is quite strong with them.
But Condition Overload obviously takes the cake with it's build up that stacks almost instantaneously with how fast you can build up Status Effects.
YES YOU CAN absolutely 100% pair a Primer with this build, but NO IT IS NOT NECESSARY to do so.
Faction Mod(s) ARE still Interchangeable
Status Effects ARE still Interchangeable

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-=-=UPDATED GUIDE=-=- (STILL RELEVANT) | Checked on 8.3.2024

So not too many changes here, just more so a different explanation needed as to how you should look at this build. I have realized Melee Duplicate is worthless on builds that end up pumping out consistent Orange/Red crits, especially consistent Red crits, so with that in mind and it being brought to my attention by someone leaving a comment that I still have Melee Duplicate on here, I've made the necessary changes.

Again, as before, you can still replace the Faction mod Primed Smite Corrupted with ANY faction mod you may desire if you'd like, or you can remove it entirely for something like Gladiator Might to stack with Organ Shatter and have synergy with the Crit Chance buildup from Blood Rush. Or any other mod you may feel like will work well or know will work well within the config.

We're going to replace Melee Duplicate with Melee Exposure. Then remove the CORROSIVE Combination from the config and replace it with the VIRAL Combination. So just replace Voltaic Strike (or whichever Electricity status mod you may have been using) with Vicious Frost (or another [Frost] mod). I also recommend replacing Primed Pressure Point with Condition Overload but if you don't then it's not going to be detrimental to your performance, there just is a noticeable difference of course if you WERE to switch to it.

Now IF you wanted and didn't care about having more Status Effects than just Heat + Corrosive on thus, since it still functions quite well with those, you COULD instead remove the extra Elemental Combination ENTIRELY and replace those two mods with Gladiator Might and Weeping Wounds. This will add extra Crit Damage, extra Crit Chance, so you'll be hitting noticeably harder and having a bit higher reds. Then that extra Status Chance for your Heat & Corrosive procs to climb much faster.

You can ALSO do whatever you may like if it works for you, this is more so just a blueprint that also efficiently functions on it's own if you AREN'T looking to make a whole personalized build. Whether you don't have time for it, don't care too much for it, or just don't necessarily know how to go about it JUST yet, then yeah here ya go.

It's versatile and very efficient on it's own, but also flexible when it comes to making changes to it if changes are desired.

To anyone struggling with Netracells, Deep Archimedeas, Elite Deep Archimedeas, or anything else involving the High Level Murmur Faction, I recommend checking this one out ==> https://overframe.gg/build/465610/nikana-prime/eradicate-the-murmur/

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----OLD GUIDE---- Still Useful Explanations

Obviously- if you have a good primer and prefer to use primers- put on [Condition Overload] in an optimal spot. Replace Primed Pressure Point or Your Chosen Faction Mod. Preferably the [Pressure Point] mod to keep the Double Dip aspect in play from your Smite Mod. <== IF YOU HAVE A PRIMER, YOU SHOULDN'T HAVE A BUNCH OF STATUS EFFECTS IN HERE, JUST CRIT CHANCE & DAMAGE BUFFS, STATUS BUILD FOR SLASH, AND CONDITION OVERLOAD FOR RAW DAMAGE

Meant to be paired with the "Eye of Lua" Umbra build- but works very well on any Warframe of course. Also HEAVILY recommend pairing any Nikana build with the Daikyu + Amalgam Daikyu Target Acquired combo for amazing healing benefits. <== RELEVANT ONLY TO UMBRA MAINS/ENJOYERS TBH

Quickening pairs well with Blood Rush for it's speed and Combo Count Chance as well as Arcane Strike for it's extra speed. Heavily recommend throwing that one on if you have that arcane maxed especially if you're wanting a free slot for something other than an Attack Speed mod on your Melee.
If you change the status effects around and only have Heat instead- or you have just Corrosive or Viral with an open slot, slotting Gladiator Might is a great option for it's extra Critical Damage and 10% Critical Chance per Combo Multiplier, synergizing well with Blood Rush <== Quickening WAS REMOVED FROM THIS CONFIG LONG AGO, BUT CAN STILL BE UTILIZED IF YOU WANNA BE A SPEED DEMON

Weeping Wounds isn't worth using unless you are specifically wanting to build up a bunch of status. Then obviously you will want a high stat chance for near infinite procs and high stacks.
I have plenty of procs with this- more than enough for it's effects to take place on Viral, Heat, Corrosive, Radiation, etc etc. <== STILL RELEVANT

Example of Percentage Consistency within Warframe
*Arcane Strike stays active for almost (literally 90%+ of the time) the whole mission for me, I'm always attacking enemies/ads. Even on single target bosses. That arcane has a 15% CHANCE OF ACTIVATING. Well if that's the case- then the status chance being at 61% is perfectly fine for what I'm presenting here. If I'm having a virtually infinite up-time on an arcane that doesn't last TOO long with only a FIFTEEN PERCENT (15%) CHANCE OF ACTIVATING. 61% is fine. Other than my personal experiences of seeing this within gameplay present itself as fact- idk how else to explain to you that building for higher status on this build is ABSOLUTELY unnecessary- UNLESS that is what you are purposefully trying to do with the personal goal you have in mind. I do not bash on personal preferences in any way whatsoever. That 15% has it's chance to proc on EVERY single hit you're throwing out- the faster you are, speed mods or not, the more virtually infinite up-time you have on Arcane Strike

People would want to argue "With that logic why do you have Blood Rush on then?".
Red Crits (Red Tier Critical Damage). You ABSOLUTELY NEED high percentages if you want Red Crits. You are NEVER going to hit red crits if your percentages aren't at least a lil over 200%.
But PLEASE REMEMBER that Red Crits are NOT NECESSARY for wild damage. You can hit crazy numbers without them being red.

Heat/Corrosive is quite the universal combination that works well in any mission and enemy type- but if you find yourself mainly against enemies with Alloy Armor I recommend testing out this Radiation/Viral build here --> Eradicate The Murmur